Govindharajan Mukund

20 | he/him | biotechnology senior @ Anna University

• 01.
  Genome Variant Interpretation Toolkit

  Full-stack bioinformatics platform for SNP and CNV analysis. Batch rsID queries, genomic coordinate mapping, and variant annotation pipelines inspired by dbSNP / ClinVar datasets.

  Live Demo GitHub
• 02.
  Landscape analysis of alzheimers disease variants

  A bioinformatics project that explores clinically reported genetic variants associated with Alzheimer's disease using the ClinVar database. The project extracts variants from established Alzheimer's-associated genes, performs data preprocessing, computes custom gene prioritization metrics, and visualizes the variant landscape. Done using python libraries.

  GitHub
• 03.
  Unified Genomic Variant Database (UGVD)

  A database that integrates critical genomic information that are usually siloed across multiple public repositories, using SQLite. The databases that have been integrated include: dbSNP, for variant identity and location, ensembl, for gene mapping and descriptions, clinVar, for clinical significance and disease associations, and gnomAD, for population-specific allele frequencies

  GitHub
• 04.
  Transcriptomic Landscapes of Breast Cancer Progression: Insights from the TCGA-BRCA Cohort

  This project investigates transcriptomic differences between Early-stage and Advanced-stage breast cancer using RNA-sequencing data from The Cancer Genome Atlas Breast Invasive Carcinoma (TCGA-BRCA) cohort.
  
  The study was conducted using R and Bioconductor packages including TCGAbiolinks, DESeq2, survival, and survminer.

  GitHub